hofmann degradation

2,3,5,6-Tetrafluoroaniline was prepared from 2,3,5,6-tetrafluorobenzoic acid as raw material through a series of reactions including acyl chlorination,amidation and Hofmann degradation.

以2,3,5,6-四氟苯甲酸为原料,经过酰氯制得酰胺后,再经霍夫曼降解制得2,3,5,6-四氟苯胺,总收率76。

2-Nitro-3-chloroaniline was synthesized from 2-nitro-3-chloro benzoic acid via acylchloride formation,amidation and Hoffmann degradation.

以2-硝基-3-氯苯甲酸为原料,由酰氯制备出酰胺后,经霍夫曼酰胺降解制得2-硝基-3-氯苯胺,研究了碱的用量、重排温度、脱羧温度和脱羧时间对降解反应的影响。